These two types are both targets of available vaccines. HPV vaccines given prior to exposure can prevent persistent genital infection and the consequent precancerous state. Depending on stage and other factors treatment may include a combination of modalities. This implies a role for an adaptive immune system in suppressing tumour progression. Surgical management of OPC carried significant morbidity with a transcervical through the neck approach, often involving mandibulotomy, in which the jawbone mandible is split. This is referred to as an open surgical technique.
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